ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0019.11-6 | New findings in adipose tissue biology | ESPEYB19

11.6. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Q Li , CE Hagberg , HS Cascales , S Lang , MT Hyvonen , F Salehzadeh , P Chen , I Alexandersson , E Terezaki , MJ Harms , M Kutschke , N Arifen , N Kramer , M Aouadi , C Knibbe , J Boucher , A Thorell , KL Spalding

kirsty.spalding@ki.se Nat Med 2021; 27(11): 1941–1953 doi: 10.1038/s41591-021-01501-8Brief Summary: This study analysed adipocytes from obese and hyperinsulinemic adults. They demonstrate that obesity is associated with the induction of a cell cycle program in mature adipocytes, leading to so-called endoreplication, as a strategy to remain fu...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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